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In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death.
At higher doses it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes.
Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are mostly used to treat allergies or cold and flu symptoms, although some first-generation antihistamines may also be used for other conditions.
Histamine-1 receptors are located in the airways, blood vessels and gastrointestinal tract (stomach and esophagus).
There are also serious paradoxical reactions that may occur in conjunction with the use of sedatives that lead to unexpected results in some individuals.
Malcolm Lader at the Institute of Psychiatry in London estimates the incidence of these adverse reactions at about 5%, even in short-term use of the drugs.This means that first-generation antihistamines are more likely to cause side effects such as sedation, dry mouth, dizziness, low blood pressure, and a rapid heart-beat.